Perturbative unitarity bounds for effective composite models

In this paper we present the partial wave unitarity bound in the parameter space of dimension-5 and dimension-6 effective operators that arise in a compositeness scenario. These are routinely used in experimental searches at the LHC to constraint contact and gauge interactions between ordinary Standard Model fermions and excited (composite) states of mass $M$. After deducing the unitarity bound for the production process of a composite neutrino, we implement such bound and compare it with the recent experimental exclusion curves for Run 2, the High-Luminosity and High-Energy configurations of the LHC. Our results also applies to the searches where a generic single excited state is produced via contact interactions. We find that the unitarity bound, so far overlooked, is quite complelling and significant portions of the parameter space ($M,\Lambda$) become excluded in addition to the standard request $M \le \Lambda$.Comment: This version of the paper merges the previous version published in Phys. Lett. B 795 (2019) 644-649 (https://doi.org/10.1016/j.physletb.2019.06.042) with the subsequent Erratum currently in press in Physics Letters B (https://doi.org/10.1016/j.physletb.2019.134990

Intraclass correlation coefficients for cluster randomized trials in care pathways and usual care: hospital treatment for heart failure.

BACKGROUND: Cluster randomized trials are increasingly being used in healthcare evaluation to show the effectiveness of a specific intervention. Care pathways (CPs) are becoming a popular tool to improve the quality of health-care services provided to heart failure patients. In order to perform a well-designed cluster randomized trial to demonstrate the effectiveness of Usual care (UC) and CP in heart failure treatment, the intraclass correlation coefficient (ICC) should be available before conducting a trial to estimate the required sample size. This study reports ICCs for both demographical and outcome variables from cluster randomized trials of heart failure patients in UC and care pathways. METHODS: To calculate the degree of within-cluster dependence, the ICC and associated 95% confidence interval were calculated by a method based on analysis of variance. All analyses were performed in R software version 2.15.1. RESULTS: ICCs for baseline characteristics ranged from 0.025 to 0.058. The median value and interquartile range was 0.043 [0.026-0.052] for ICCs of baseline characteristics. Among baseline characteristics, the highest ICCs were found for admission by referral or admission from home (ICC = 0.058) and the disease severity at admission (ICC = 0.046). Corresponding ICCs for appropriateness of the stay, length of stay and hospitalization cost were 0.069, 0.063, and 0.001 in CP group and 0.203, 0.020, 0.046 for usual care, respectively. CONCLUSION: Reported values of ICCs from present care pathway trial and UC results for some common outcomes will be helpful for estimating sample size in future clustered randomized heart failure trials, in particular for the evaluation of care pathways

Reducing clinical variations with clinical pathways: do pathways work?

OBJECTIVE: To test clinical pathways in a variety of Italian health care organizations in 2000-2002 to measure performance in decreasing process and outcome variations. DESIGN: Creation of indicators, specific for each clinical pathway, to measure variations in the care processes and outcomes. Pre- and post-analysis model to evaluate the possible effect of the clinical pathways on each indicator. SETTING: We tested the clinical pathways in six sites, each with different clinical pathways. RESULTS: Reductions in health care macro-variation phenomena (length of stay, patient pathways, etc.) and in performance micro-variation (variations in diagnostic and therapeutic prescriptions, protocol implementation, etc.) were shown in sites where pathways were implemented successfully. A significant improvement in outcome for patients who were treated according to the clinical pathway for heart failure was also demonstrated. CONCLUSIONS: The overall purpose of clinical pathways is to improve outcome by providing a mechanism to coordinate care and to reduce fragmentation, and ultimately cost. Our results demonstrated that it is possible to achieve this goal. Although controversial elements still exist, we think that clinical pathways can have a positive impact on quality in health care

Single Top Production at the Next Generation Linear e+e- Colliders

Present limits on the top mass from LEP1 and Tevatron point to a top quark that is considerably heavier than the $W$ vector boson in the standard model. Hence, e+e- colliders with \sqrt{s} \simeq 300 GeV (the c.m. energy foreseen at the first phase of the Next Linear e+e- Collider) could be well below the energy threshold for real top-pair production. We argue that, if this is the case, single top production through the process e+e- --> t\bar{b}W- (\bar{t}bW+), where t\bar{b} (\bar{t}b) are produced mainly by means of a virtual W, becomes the dominant top production mechanism. Total cross sections and kinematical distributions are evaluated and numerical results are given in ranges of m_t and \sqrts{s} where single top production can be of relevance. The relative importance of virtual-W and virtual-t contributions to the process is discussed.Comment: 20 pages, LaTeX + feynman.tex, 10 compressed (tar.Z) postscript figures included in a separate uuencoded file, revised version of Rome1 Preprint n.979 (1993), Dec 29, 1993. (In this revised version -- accepted for publication on Zeit. fur Phys.C in Jan 24, 1994 -- some sentences and 3 new refs. have been added with respect to the first one

New exact solution of the one dimensional Dirac Equation for the Woods-Saxon potential within the effective mass case

We study the one-dimensional Dirac equation in the framework of a position dependent mass under the action of a Woods-Saxon external potential. We find that constraining appropriately the mass function it is possible to obtain a solution of the problem in terms of the hypergeometric function. The mass function for which this turns out to be possible is continuous. In particular we study the scattering problem and derive exact expressions for the reflection and transmission coefficients which are compared to those of the constant mass case. For the very same mass function the bound state problem is also solved, providing a transcendental equation for the energy eigenvalues which is solved numerically.Comment: Version to match the one which has been accepted for publication by J. Phys. A: Math. Theor. Added one figure, several comments and few references. (24 pages and 7 figures

Erratum to: “Perturbative unitarity bounds for effective composite models” [Phys. Lett. B 795 (2019) 644-649]

Numerical results for the partial wave unitarity bounds on the parameter space (Lambda, M) of dimension-6 effective operators of a composite scenario presented in Biondini et al. (2019) [1] are revised. Figs. 2-5 and Table 1 are to be replaced by the following corresponding figures and table. We briefly comment on the impact on the conclusions presented in the original article

Is it possible to predict the success of non-invasive positive pressure ventilation in acute respiratory failure due to COPD?

AbstractThere is now sufficient evidence that non-invasive positive pressure ventilation (NIPPV) in selected patients with severe hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease (COPD) is more effective than pharmacological therapy alone. The aim of this study was to identify prognostic factors to predict the success of this technique. Fifty-nine consecutive patients with COPD admitted to a respiratory ward for 75 episodes of acute respiratory failure treated with NIPPV were analysed: success (77%) or failure (23%) were evaluated by survival and the need for endotracheal intubation. There were no significant differences in age, sex, cause of relapse and lung function tests between the two groups. Patients in whom NIPPV was unsuccessful were significantly underweight, had an higher Acute Physiology and Chronic Health Evaluation (APACHE) II score, and a lower serum level of albumin in comparison with those in whom NIPPV was successful. They demonstrated significantly greater abnormalities in pH and P a CO2at baseline and after 2 h of NIPPV. The logistic regression analysis demonstrated that, when all the variables were tested together, a high APACHE II score and a low albumin level continued to have a significant predictive effect. This analysis could predict the outcome in 82% of patients. In conclusion, our study suggests that low albumin serum levels and a high APACHE II score may be important indices in predicting the success of NIPPV

Eight-step method to build the clinical content of an evidence-based care pathway: the case for COPD exacerbation

Abstract Background Optimization of the clinical care process by integration of evidence-based knowledge is one of the active components in care pathways. When studying the impact of a care pathway by using a cluster-randomized design, standardization of the care pathway intervention is crucial. This methodology paper describes the development of the clinical content of an evidence-based care pathway for in-hospital management of chronic obstructive pulmonary disease (COPD) exacerbation in the context of a cluster-randomized controlled trial (cRCT) on care pathway effectiveness. Methods The clinical content of a care pathway for COPD exacerbation was developed based on recognized process design and guideline development methods. Subsequently, based on the COPD case study, a generalized eight-step method was designed to support the development of the clinical content of an evidence-based care pathway. Results A set of 38 evidence-based key interventions and a set of 24 process and 15 outcome indicators were developed in eight different steps. Nine Belgian multidisciplinary teams piloted both the set of key interventions and indicators. The key intervention set was judged by the teams as being valid and clinically applicable. In addition, the pilot study showed that the indicators were feasible for the involved clinicians and patients. Conclusions The set of 38 key interventions and the set of process and outcome indicators were found to be appropriate for the development and standardization of the clinical content of the COPD care pathway in the context of a cRCT on pathway effectiveness. The developed eight-step method may facilitate multidisciplinary teams caring for other patient populations in designing the clinical content of their future care pathways.</p